Bodnar Richard J, Klein Gad E
Department of Psychology and Neuropsychology Doctoral Sub-Program, Queens College, City University of New York, 65-30 Kissena Blvd., Flushing, NY 11367, USA.
Peptides. 2006 Dec;27(12):3391-478. doi: 10.1016/j.peptides.2006.07.011. Epub 2006 Sep 12.
This paper is the 28th consecutive installment of the annual review of research concerning the endogenous opioid system, now spanning over a quarter-century of research. It summarizes papers published during 2005 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides, opioid receptors, opioid agonists and opioid antagonists. The particular topics that continue to be covered include the molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors related to behavior (Section 2), and the roles of these opioid peptides and receptors in pain and analgesia (Section 3); stress and social status (Section 4); tolerance and dependence (Section 5); learning and memory (Section 6); eating and drinking (Section 7); alcohol and drugs of abuse (Section 8); sexual activity and hormones, pregnancy, development and endocrinology (Section 9); mental illness and mood (Section 10); seizures and neurologic disorders (Section 11); electrical-related activity, neurophysiology and transmitter release (Section 12); general activity and locomotion (Section 13); gastrointestinal, renal and hepatic functions (Section 14); cardiovascular responses (Section 15); respiration and thermoregulation (Section 16); immunological responses (Section 17).
本文是关于内源性阿片系统研究年度综述的第28期连续刊文，该综述如今已涵盖超过四分之一世纪的研究。它总结了2005年发表的研究阿片肽、阿片受体、阿片激动剂和阿片拮抗剂的分子、药理学及基因操作的行为学效应的论文。持续涵盖的特定主题包括与行为相关的内源性阿片及其受体的分子生化效应和神经化学定位研究（第2节），以及这些阿片肽和受体在疼痛与镇痛（第3节）、应激与社会地位（第4节）、耐受性与依赖性（第5节）、学习与记忆（第6节）、饮食（第7节）、酒精与滥用药物（第8节）、性活动与激素、妊娠、发育与内分泌学（第9节）、精神疾病与情绪（第10节）、癫痫与神经疾病（第11节）、电相关活动、神经生理学与递质释放（第12节）、一般活动与运动（第13节）、胃肠、肾脏与肝脏功能（第14节）、心血管反应（第15节）、呼吸与体温调节（第16节）、免疫反应（第17节）中的作用。
