Hong Chang-Soo, Saint-Jeannet Jean-Pierre
Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Semin Cell Dev Biol. 2005 Dec;16(6):694-703. doi: 10.1016/j.semcdb.2005.06.005. Epub 2005 Jul 21.
Among the families of transcription factors expressed at the neural plate border in response to neural crest-inducing signals, Sox proteins have emerged as important players in regulating multiple aspects of neural crest development. Here, we summarize the expression of six Sox genes, namely Sox8, Sox9, Sox10, LSox5, Sox4 and Sox11, in neural crest progenitors and their derivatives, and review some aspects of their function pertaining to neural crest development in several species.
在响应神经嵴诱导信号而在神经板边界表达的转录因子家族中，Sox蛋白已成为调节神经嵴发育多个方面的重要因子。在此，我们总结了六个Sox基因，即Sox8、Sox9、Sox10、LSox5、Sox4和Sox11在神经嵴祖细胞及其衍生物中的表达情况，并综述了它们在几个物种中与神经嵴发育相关的一些功能方面。
