Schmiedt Christina, Meistrowitz Anette, Schwendemann Günter, Herrmann Manfred, Basar-Eroglu Canan
Institute for Psychology and Cognition Research, University of Bremen, Grazer Str. 4, Bremen D-28359, Germany.
Neurosci Lett. 2005 Nov 18;388(3):138-43. doi: 10.1016/j.neulet.2005.06.049.
The aim of the present study was to investigate alterations in brain oscillatory activity during transient intentional encoding of abstract novel shapes in patients with Parkinson's disease (PD). Combined time-frequency analyses of alpha and theta power revealed a clear dissociation between PD patients (N=10) and age-matched healthy controls (N=10). PD patients used sub-optimal stimulus encoding strategies for subsequent maintenance and recall, whereas the controls mainly used categorization processes. In contrast to controls, PD patients showed significantly less theta increase and upper alpha suppression at frontal locations and significant laterality of early posterior theta and lower-2 alpha oscillations at right posterior locations. These findings suggest that the fronto-striatal circuits participate in visual categorization processes. Furthermore, theta and alpha oscillations appear to be involved in mediating the integration processes in mnemonic networks underlying visual categorization.
本研究的目的是调查帕金森病（PD）患者在短暂有意编码抽象新形状时脑振荡活动的变化。对α和θ功率进行联合时频分析发现，PD患者（N = 10）与年龄匹配的健康对照者（N = 10）之间存在明显差异。PD患者在后续的维持和回忆中使用了次优的刺激编码策略，而对照组主要使用分类过程。与对照组相比，PD患者在额叶部位的θ增加和上部α抑制明显较少，并且在右后部位置早期后部θ和下部-2α振荡存在明显的偏侧性。这些发现表明，额纹状体回路参与视觉分类过程。此外，θ和α振荡似乎参与介导视觉分类背后记忆网络中的整合过程。
