Dushanova Juliana, Philipova Dolja, Nikolova Gloria
Institute of Neurobiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
Cell Mol Neurobiol. 2009 Sep;29(6-7):971-80. doi: 10.1007/s10571-009-9384-4. Epub 2009 Mar 17.
Parkinson's disease is a neurodegenerative disorder with symptoms, which include movement disturbances and changes of cognitive information processing. The aim of the present study was to investigate the functional relationships between oscillatory electroencephalographic (EEG) dominant components with event-related desynchronization/synchronization (ERD/ERS) method for idiopathic non-demented Parkinson's patients (PP) and control subjects (CS) during auditory discrimination tasks within two post-stimulus intervals of 0-250 and 250-600 ms. When comparing the CS and PP during the first post-stimulus period, we found delta- and theta-ERS significantly pronounced in CS for both tone types (low--800, high--1,000 Hz) with the following exceptions: at Fz, PP displayed higher delta-ERS, while at C3' theta-ERD in response to a high tone. Alpha-ERS was found in PP in response to either tone at all electrodes and mainly alpha-ERD in CS. In the second post-stimulus interval, the significant differences between the groups were: (i) delta-ERS in CS and delta-ERD in PP in response to the low tone and (ii) delta-ERS for both groups in answer to the high tone, more prominent in CS at Cz and Pz, except for delta-ERD in PP at C3'. For both groups, we detected predominantly theta-ERD and alpha-ERD following both tone types within this second interval. PP showed more expressed theta-ERD at Fz and parietal theta-ERS. Alpha-ERD was significantly higher in CS, while frontal alpha-ERD was more prominent in the PP in response to both tones. The data obtained showed specific functional differences of event-related oscillatory activity in cognitive and sensory-motor information processing between the PP and CS.
帕金森病是一种神经退行性疾病，其症状包括运动障碍和认知信息处理的变化。本研究的目的是，在0 - 250毫秒和250 - 600毫秒这两个刺激后间隔内的听觉辨别任务中，采用事件相关去同步化/同步化（ERD/ERS）方法，研究特发性非痴呆帕金森病患者（PP）和对照组受试者（CS）的振荡性脑电图（EEG）主导成分之间的功能关系。在刺激后的第一个时间段比较CS和PP时，我们发现，对于两种音调类型（低音 - 800赫兹，高音 - 1000赫兹），CS中的δ波和θ波ERS明显更显著，但有以下例外情况：在Fz电极处，PP显示出更高的δ波ERS，而在C3'电极处，PP对高音的反应为θ波ERD。在所有电极处，PP对任何一种音调的反应均出现α波ERS，而CS中主要是α波ERD。在刺激后的第二个间隔期，两组之间的显著差异为：（i）CS对低音的δ波ERS和PP对低音的δ波ERD；（ii）两组对高音的δ波ERS，在Cz和Pz电极处CS更显著，但C3'电极处PP为δ波ERD除外。在第二个间隔期内，对于两组而言，在两种音调类型之后，我们主要检测到θ波ERD和α波ERD。PP在Fz电极处显示出更明显的θ波ERD和顶叶θ波ERS。CS中的α波ERD显著更高，而PP对两种音调的反应中额叶α波ERD更显著。所获得的数据显示，PP和CS在认知和感觉运动信息处理方面，事件相关振荡活动存在特定的功能差异。
