Bagros P, Aparicio M
Service néphrologie, hôpital Bretonneau, Tours.
Rev Prat. 1992 Feb 15;42(4):417-20.
Nephrotic syndrome causes hypercholesterolemia. Chronic renal failure results in hypertriglyceridemia, low HDL cholesterol and, more often, apolipoprotein abnormalities. This dyslipidemia is not corrected by hemodialysis. Transplantation corrects it but leads to other kinds of lipid abnormalities. Whether the treatment of these potentially atherogenetic abnormalities is beneficial of not remains unproved. There is some evidence of lipid contribution to the constitution of glomerulosclerosis in animals but it remains hypothetical in man.
肾病综合征可导致高胆固醇血症。慢性肾衰竭会引起高甘油三酯血症、高密度脂蛋白胆固醇降低，且更常见的是载脂蛋白异常。这种血脂异常无法通过血液透析得到纠正。肾移植可纠正血脂异常，但会导致其他类型的脂质异常。这些潜在的致动脉粥样硬化异常的治疗是否有益尚无定论。有证据表明脂质在动物肾小球硬化的形成中起作用，但在人类中仍属假设。
