Avis Nancy E, Smith Kevin W, McGraw Sarah, Smith Roselyn G, Petronis Vida M, Carver Charles S
Wake Forest University School of Medicine, Department of Public Health Sciences, Winston-Salem, NC 27157-1063, USA.
Qual Life Res. 2005 May;14(4):1007-23. doi: 10.1007/s11136-004-2147-2.
This article describes development of a quality of life measure designed to assess issues relevant to long-term cancer survivors. In-depth semi-structured interviews were conducted with 58 long-term cancer survivors to identify domains most relevant to long-term survivors (> or = 5 years post-diagnosis). Self-report items were developed from these interviews and administered to a second sample of 242 long-term survivors. Domains and items were selected from the item pool by a combination of factor analysis and criterion-based item selection. Five cancer-specific domains were identified (appearance concerns, financial problems, distress over recurrence, family-related distress, and benefits of cancer) along with seven generic QOL domains (negative feelings, positive feelings, cognitive problems, sexual problems, physical pain, fatigue, and social avoidance). Cronbach's alpha was 0.72 or greater for each domain. Correlations between domain scores and criterion measures were 0.72 or higher in all but one generic domain (social avoidance), but somewhat lower on cancer-specific domains. The new multidimensional measure has good internal consistency and validity and is appropriate for comparisons between cancer and non-cancer populations, as well as long-term follow-up of cancer patients.
本文描述了一种生活质量测量方法的开发，该方法旨在评估与长期癌症幸存者相关的问题。对58名长期癌症幸存者进行了深入的半结构化访谈，以确定与长期幸存者（诊断后5年及以上）最相关的领域。从这些访谈中开发了自我报告项目，并将其应用于由242名长期幸存者组成的第二个样本。通过因素分析和基于标准的项目选择相结合的方式，从项目库中选择领域和项目。确定了五个癌症特定领域（外貌担忧、财务问题、对复发的困扰、与家庭相关的困扰以及癌症的益处）以及七个通用生活质量领域（负面情绪、正面情绪、认知问题、性问题、身体疼痛、疲劳和社交回避）。每个领域的克朗巴赫α系数为0.72或更高。除了一个通用领域（社交回避）外，所有领域得分与标准测量之间的相关性均为0.72或更高，但在癌症特定领域的相关性略低。这种新的多维测量方法具有良好的内部一致性和效度，适用于癌症人群与非癌症人群之间的比较，以及癌症患者的长期随访。
