Lee Peng, Gao Wanrong, Zhang Xianling
Department of Optical Engineering, School of Electronic Engineering and Optoelectronic Technique,Nanjing University of Science and Technology, 200 Xiao Ling Wei, Nanjing, Jiangsu 210094, China.
Appl Opt. 2010 Jun 20;49(18):3538-44. doi: 10.1364/AO.49.003538.
Tissue optical properties can be determined with optical coherence tomography (OCT) by fitting a model to the OCT signal. Using calibrated samples in the fixed focus geometry, the validity of the single-scattering and multiple-scattering models for both highly scattering and weakly scattering media (scattering coefficients mu(s) ranging from 1.25 to 25.11mm(-1)) has been investigated. The results show that, with a proper correction for the confocal properties of the sample arm, both models are appropriate to extract the scattering coefficients of weakly scattering media. For highly scattering media, the multiple scattering should be taken into account, and the multiple-scattering model can provide higher accuracy. Finally, the scattering properties of in vitro rat liver and in vivo human skin are determined. The results are useful for quantitatively characterizing tissue scattering in biomedical research and clinical diagnosis.
组织光学特性可通过将模型拟合到光学相干断层扫描（OCT）信号，利用OCT来确定。在固定焦点几何结构中使用校准样本，研究了单散射和多散射模型对于高散射和弱散射介质（散射系数μ(s)范围为1.25至25.11mm(-1)）的有效性。结果表明，对样品臂的共焦特性进行适当校正后，两种模型都适用于提取弱散射介质的散射系数。对于高散射介质，应考虑多次散射，多散射模型可提供更高的精度。最后，测定了体外大鼠肝脏和体内人体皮肤的散射特性。这些结果对于生物医学研究和临床诊断中组织散射的定量表征很有用。
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