Lim E T, Berger T, Reindl M, Dalton C M, Fernando K, Keir G, Thompson E J, Miller D H, Giovannoni G
Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.
Mult Scler. 2005 Aug;11(4):492-4. doi: 10.1191/1352458505ms1187sr.
This study investigates whether the presence of serum and plasma anti-myelin oligodendrocyte glycoprotein (MOG) and anti-myelin basic protein (MBP) in patients presenting with a clinically isolated syndrome compatible with demyelination (CIS) predicts early conversion to multiple sclerosis (MS). Forty-seven patients with CIS (46 with optic neuritis) had anti-MOG and anti-MBP antibodies analysed at baseline, and clinical and magnetic resonance imaging assessments. There was no evidence that the MS status based on either the McDonald or Poser criteria relates to the antibody status.
本研究调查了临床孤立综合征伴脱髓鞘表现（CIS）患者血清和血浆中抗髓鞘少突胶质细胞糖蛋白（MOG）及抗髓鞘碱性蛋白（MBP）的存在是否能预测其早期转化为多发性硬化症（MS）。47例CIS患者（46例患有视神经炎）在基线时接受了抗MOG和抗MBP抗体分析以及临床和磁共振成像评估。没有证据表明基于麦克唐纳或波泽标准的MS状态与抗体状态有关。
