Renier G, Renier J C, François S, Chevailler A, Ifrah N, Hurez D
Laboratoire d'Immunopathologie, CHRU, Angers.
Rev Rhum Mal Osteoartic. 1992 Feb;59(2):155-8.
Two cases of the association of monoclonal IgM and ankylosing spondylitis are reported. Their presentations are in accordance with local epidemiological data (monoclonal IgM, both kappa, one of them malignant, discovered in 71 and 79 year-old men). Ankylosing spondylitis does not appear as either favouring the incidence of monoclonal immunoglobulins or, in our opinion, having a major influence on their isotype. Conversely, while each member of this association could have its own story, the possible role of the coexistence of HLA B27 together with ankylosing spondylitis should be considered.
报告了两例单克隆IgM与强直性脊柱炎相关的病例。其临床表现与当地流行病学数据相符（单克隆IgM，均为κ型，其中一例为恶性，分别在71岁和79岁男性中发现）。强直性脊柱炎似乎既不促进单克隆免疫球蛋白的发生，在我们看来，也不对其同种型产生重大影响。相反，虽然这种关联中的每个成员可能都有其自身情况，但应考虑HLA B27与强直性脊柱炎共存的可能作用。
