吡咯喹啉醌促进大鼠坐骨神经横断后的再生。

Pyrroloquinoline quinone enhances regeneration of transected sciatic nerve in rats.

作者信息

Li Hao-huan, Liu Shi-qing, Peng Hao, Zhang Nu

机构信息

Department of Orthopedics, Ren Min Hospital, Wuhan University, China.

出版信息

Chin J Traumatol. 2005 Aug;8(4):225-9.

PMID:16042869

Abstract

OBJECTIVE

To investigate the effect of pyrroloquinoline quinone (PQQ) on nerve regeneration of transected sciatic nerve in animal models.

METHODS

Forty SD rats weighing 220-240 g were randomized into a PQQ group (n = 20) and a control group (n = 20). Each animal underwent sciatic nerve transection operation. After the operation, PQQ 0.5 ml (250 microg/Kg) was injected at the operation site in the PQQ group, while the same volume of normal saline was delivered in the control group. Nerve functional evaluation, electrophysiological index recording were carried out according to the experimental design. Newly generated nerve specimens were harvested 12 weeks postoperatively for morphological studies.

RESULTS

In the PQQ group there was a good nerve regeneration and the sciatic nerve function, sciatic nerve function index, electrophysiological index and morphological appearance were superior to the control group (P < 0.05).

CONCLUSIONS

PQQ has a remarkable effect in enhancing nerve regeneration of transected peripheral nerve.

摘要

目的

研究吡咯喹啉醌（PQQ）对动物模型中坐骨神经横断后神经再生的影响。

方法

将40只体重220 - 240克的SD大鼠随机分为PQQ组（n = 20）和对照组（n = 20）。每组动物均接受坐骨神经横断手术。术后，PQQ组在手术部位注射0.5毫升（250微克/千克）PQQ，而对照组注射相同体积的生理盐水。根据实验设计进行神经功能评估和电生理指标记录。术后12周采集新生神经标本进行形态学研究。