Gümüs Bilal, Kuyucu Ersin, Erbas Oytun, Kazimoglu Cemal, Oltulu Fatih, Bora Osman Arslan
Department of Orthopaedics and Traumatology, Izmir Ataturk Training and Research Hospital, Izmir, Turkey.
Orthopaedics & Traumatology, Istanbul Medipol University, TEM Avrupa Göztepe çıkışı, No: 1 Bağcılar, Istanbul, Turkey.
J Orthop Surg Res. 2015 Oct 14;10:161. doi: 10.1186/s13018-015-0301-x.
Growth factors such as nerve growth factor (NGF) and insulin-like growth factor-1 (IGF-1) have been shown to play a role in the healing process of nerve injury. Recent researches have also shown that oxytocin administration activates these growth factors of importance for the healing of nerve tissue. The objective of the present study was to evaluate the effects of oxytocin on peripheral nerve regeneration in rats.
Twenty-four male Sprague-Dawley rats were underwent transection damage model on the right sciatic nerve and defective damage model on the left sciatic nerve. The animals were assigned to one of two groups: control group or treatment group (received 80 mg/kg oxytocin intraperitoneally for 12 weeks). The sciatic nerve was examined, both functionally (on the basis of climbing platform test) and histologically (on the basis of axon count), 3, 6, 9, and 12 weeks after the injury. Also, stereomicroscopic and electrophysiological evaluations were carried out.
Significantly greater improvements in electrophysiological recordings and improved functional outcome measures were presented in the treatment group at 12-week follow-up. Stereomicroscopic examinations disclosed prominent increases in vascularization on proximal cut edges in the oxytocin group in comparison with the control group. Higher axon counts were also found in this group.
Intraperitoneal oxytocin administration resulted in accelerated functional, histological, and electrophysiological recovery after different sciatic injury models in rats.
神经生长因子（NGF）和胰岛素样生长因子-1（IGF-1）等生长因子已被证明在神经损伤的愈合过程中发挥作用。最近的研究还表明，给予催产素可激活这些对神经组织愈合至关重要的生长因子。本研究的目的是评估催产素对大鼠周围神经再生的影响。
24只雄性Sprague-Dawley大鼠，右侧坐骨神经进行横断损伤模型，左侧坐骨神经进行缺损损伤模型。将动物分为两组之一：对照组或治疗组（腹腔注射80mg/kg催产素，持续12周）。在损伤后3、6、9和12周，对坐骨神经进行功能（基于爬台试验）和组织学（基于轴突计数）检查。此外，还进行了体视显微镜和电生理评估。
在12周随访时，治疗组的电生理记录有明显更大的改善，功能结果测量也有所改善。体视显微镜检查显示，与对照组相比，催产素组近端切缘的血管化显著增加。该组的轴突计数也更高。
腹腔注射催产素可使大鼠不同坐骨损伤模型后的功能、组织学和电生理恢复加速。
