Tillisch Kirsten, Chang Lin
VA Greater Los Angeles Healthcare System, CURE Building 115, Room 223, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA.
Curr Gastroenterol Rep. 2005 Aug;7(4):249-56. doi: 10.1007/s11894-005-0016-y.
Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder with a wide variety of presentations that may include abdominal pain, bloating, diarrhea, constipation, or alternating bowel habits. Symptom-based criteria and a limited medical evaluation are used for diagnosis. The heterogeneity of IBS presenting symptoms, together with the pathophysiology of the disorder, is unclear, making treatment challenging. Treatment strategies are focused on specific symptoms, potential underlying disorders in stress responsiveness, and predisposing psychological features. Although only two medications, tegaserod for constipation-predominant IBS and alosetron for diarrhea-predominant IBS, are specifically indicated, a wide variety of treatment options are available and are discussed in this review.
肠易激综合征（IBS）是一种常见的功能性胃肠疾病，有多种表现形式，可能包括腹痛、腹胀、腹泻、便秘或排便习惯交替。诊断采用基于症状的标准和有限的医学评估。IBS呈现症状的异质性以及该疾病的病理生理学尚不清楚，这使得治疗具有挑战性。治疗策略侧重于特定症状、应激反应中潜在的基础疾病以及易患的心理特征。尽管仅两种药物，即用于以便秘为主的IBS的替加色罗和用于以腹泻为主的IBS的阿洛司琼有明确适应证，但仍有多种治疗选择，本文将对这些选择进行讨论。
