Brody Harold J
Department of Dermatology, Emory University School of Medicine, Atlanta, GA 30327, USA.
Dermatol Surg. 2005 Aug;31(8 Pt 1):893-7. doi: 10.1097/00042728-200508000-00001.
In the past, reactions or misplacement of soft tissue fillers has been fraught with anxiety because time has been the main thrust for improvement in spite of ancillary treatments. Hyaluronidase is an enzyme that dissolves hyaluronic acid in the skin and also assists in the management of granulomatous foreign-body reactions to hyaluronic acid. These reactions may be caused by allergy to the material or immunologic response to the protein contaminants in the hyaluronic acid preparations. Dissolution of material in erroneous placement of material and in allergic reactions can be a time saver and a deterrent to patient dissatisfaction.
To evaluate the use of hyaluronidase in the treatment of both allergic reactions and the erroneous misplacement of hyaluronic acid in the skin.
A case of persistent granulomatous reaction to injectable hyaluronic acid and a case of hyaluronic acid erroneous misplacement with their successful subsequent treatments using intracutaneous hyaluronidase are reported, along with illustrative examples of hyaluronidase use.
The use of hyaluronidase reduced the patient discomfort within 24 to 48 hours, deterring any patient anxiety or patient dissatisfaction.
Hyaluronidase has a place in the treatment of allergic reactions to hyaluronic acid [corrected] and in the erroneous misplacement of the material.
过去，软组织填充剂的反应或误置一直令人焦虑，因为尽管有辅助治疗，但时间一直是改善的主要推动力。透明质酸酶是一种能溶解皮肤中透明质酸的酶，也有助于处理对透明质酸的肉芽肿性异物反应。这些反应可能由对材料的过敏或对透明质酸制剂中蛋白质污染物的免疫反应引起。溶解误置的材料以及过敏反应中的材料可以节省时间并防止患者不满。
评估透明质酸酶在治疗皮肤过敏反应和透明质酸误置方面的应用。
报告了一例对可注射透明质酸持续的肉芽肿反应病例和一例透明质酸误置病例，以及随后使用皮内注射透明质酸酶成功治疗的病例，并举例说明了透明质酸酶的使用情况。
使用透明质酸酶在24至48小时内减轻了患者的不适，消除了患者的焦虑或不满。
透明质酸酶在治疗对透明质酸的过敏反应[已修正]和材料误置方面有一定作用。
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