Kashanian M, Akbarian A R, Soltanzadeh M
Iran University of Medical Sciences and Health Services. Department of Obstetrics and Gynecology, Akbar Abadi Teaching Hospital, Tehran, Iran.
Int J Gynaecol Obstet. 2005 Oct;91(1):10-4. doi: 10.1016/j.ijgo.2005.06.005.
To perform a comparison between atosiban (oxytocin antagonist) and nifedipin (calcium channel blocker) for acute treatment of preterm labor and their maternal safety.
A randomized controlled trial study was performed on 80 pregnant women with preterm labor, between 26 and 34 weeks of pregnancy, in Akbar Abadi Teaching Hospital in Tehran, Iran. 40 women (the atosiban group) were compared with another 40 women (the nifedipin group) for the drugs' efficacy in delaying delivery for more than 48 h in order to undergo steroid therapy, and for more than 7 days or more, and also to assess their maternal safety. The duration between the drugs' administration and delivery were compared. The statistical analysis was performed using the Statistical Package for Social Science (SPSS).
There was no statistically significant difference between the two groups in the treatment of preterm labor. Atosiban was effective in 82.5% of cases, and nifedipin in 75% of the cases (p=1.000), for delaying delivery for 48 h. Atosiban was effective in 75% of the cases, and nifedipin in 65% of the cases, for delaying delivery for more than 7 days. The maternal side effects in the atosiban group were 17.5%, and in the nifedipin group they were 40%, which had a statistically significant difference (p=0.027). The duration between treatment and delivery was 29.03+/-16.12 days in the atosiban group and 22.85+/-13.9 days in the nifedipin group with no statistically significant difference (p=0.79).
Atosiban is an effective and safe drug for the acute treatment of preterm labor with minimal side effects, and it can be an option in the treatment of preterm labor, especially in patients with heart disease and multi-fetal pregnancies.
比较阿托西班（催产素拮抗剂）和硝苯地平（钙通道阻滞剂）用于早产急性治疗的效果及其对母体的安全性。
在伊朗德黑兰的阿克巴阿巴迪教学医院，对80例孕周在26至34周的早产孕妇进行了一项随机对照试验研究。将40名妇女（阿托西班组）与另外40名妇女（硝苯地平组）比较这两种药物在延迟分娩超过48小时以便进行类固醇治疗、延迟分娩超过7天或更长时间方面的疗效，并评估它们对母体的安全性。比较了给药至分娩的时间。使用社会科学统计软件包（SPSS）进行统计分析。
两组在早产治疗方面无统计学显著差异。阿托西班在82.5%的病例中有效，硝苯地平在75%的病例中有效（p = 1.000），可延迟分娩48小时。阿托西班在75%的病例中有效，硝苯地平在65%的病例中有效，可延迟分娩超过7天。阿托西班组的母体副作用为17.5%，硝苯地平组为40%，具有统计学显著差异（p = 0.027）。阿托西班组治疗至分娩的时间为29.03±16.12天，硝苯地平组为22.85±13.9天，无统计学显著差异（p = 0.79）。
阿托西班是一种用于早产急性治疗的有效且安全的药物，副作用极小，可作为早产治疗的一种选择，尤其适用于患有心脏病和多胎妊娠的患者。
