Harpold Terri L, Wozniak Janet, Kwon Anne, Gilbert Jennifer, Wood Julia, Smith Laura, Biederman Joseph
Clinical and Research Program in Pediatric Psychopharmacology, Johnson and Johnson Center for the Study of Pediatric Psychopathology, Massachusetts General Hospital and Harvard Medical School, USA.
J Affect Disord. 2005 Sep;88(1):19-26. doi: 10.1016/j.jad.2005.05.016.
To examine the association between anxiety (ANX) and bipolar disorders (BPD) in a clinically referred pediatric sample.
Subjects were consecutively referred youth aged <18 years, with a DSM-III-R/DSM-IV diagnosis of BPD (n=297) or a disruptive behavior disorder (DBD) (n=1100) on structured interview.
Bipolar disorder in youth was associated with a significantly increased risk for most of the DSM-IV anxiety disorders and was not specifically linked to any one disorder in particular.
Bipolar disorder in youth is a significant risk factor for anxiety comorbidity. Considering the morbidity and dysfunction as well as the differing therapeutic needs associated with bipolar and anxiety symptomatology, appropriate therapeutic approaches will be needed for the management of youth with this comorbidity.
在一个临床转诊的儿科样本中研究焦虑症（ANX）与双相情感障碍（BPD）之间的关联。
研究对象为年龄小于18岁的连续转诊青少年，通过结构化访谈确诊为DSM-III-R/DSM-IV双相情感障碍（n = 297）或破坏性行为障碍（DBD）（n = 1100）。
青少年双相情感障碍与大多数DSM-IV焦虑症的风险显著增加相关，且并非特别与某一种特定障碍相关。
青少年双相情感障碍是焦虑症共病的一个重要风险因素。考虑到双相情感障碍和焦虑症状相关的发病率、功能障碍以及不同的治疗需求，对于患有这种共病的青少年需要采取适当的治疗方法。
