Schreurs Bernard G, Smith-Bell Carrie A
Blanchette Rockefeller Neurosciences Institute, Department of Physiology and Pharmacology, West Virginia University, Morgantown, USA.
Neurobiol Learn Mem. 2005 Sep;84(2):148-58. doi: 10.1016/j.nlm.2005.06.003.
Conditioning-specific reflex modification (CRM) of the rabbit's nictitating membrane response (NMR) involves changes in responding to an unconditioned stimulus (US) when the US is tested in the absence of the conditioned stimulus. Previous experiments have shown that CRM is a function of the type and intensity of the aversive US used during classical conditioning. As a result, it has been suggested that CRM may be mediated, at least in part, by the aversiveness of the US. Here, we show that by using a moderately intense electrical pulse to the skin as a US, CRM of the rabbit NMR is accompanied by an increase in heart rate. The largest changes in heart rate occur at US intensities that produce the strongest levels of CRM. The heart rate data show that there may be an increased emotional/arousal component to the US that is correlated with CRM and support the use of CRM as a potential model for posttraumatic stress disorder.
家兔瞬膜反应（NMR）的条件特异性反射修饰（CRM）涉及在无条件刺激（US）在没有条件刺激的情况下进行测试时，对无条件刺激的反应变化。先前的实验表明，CRM是经典条件反射过程中使用的厌恶性无条件刺激的类型和强度的函数。因此，有人提出CRM可能至少部分地由无条件刺激的厌恶性介导。在这里，我们表明，通过使用适度强烈的皮肤电脉冲作为无条件刺激，家兔NMR的CRM伴随着心率增加。心率的最大变化发生在产生最强CRM水平的无条件刺激强度下。心率数据表明，无条件刺激可能存在增加的情绪/唤醒成分，这与CRM相关，并支持将CRM用作创伤后应激障碍的潜在模型。
