Schreurs Bernard G, Crum Jennifer M, Wang Desheng, Smith-Bell Carrie A
Blanchette Rockefeller Neurosciences Institute and Department of Physiology and Pharmacology, West Virginia University, Morgantown, WV 26506, USA.
Behav Neurosci. 2005 Dec;119(6):1484-95. doi: 10.1037/0735-7044.119.6.1484.
Conditioning-specific reflex modification (CRM) describes changes in rabbit (Oryctolagus cuniculus) nictitating membrane responses (NMR) to an unconditioned stimulus (US) when the US is tested by itself after pairings of tone and electrodermal stimulation. Although CRM has been replicated, it is unclear whether it occurs in response systems other than that of the NMR. The authors report that CRM of rabbit heart rate (HR) can occur following HR conditioning. A US that elicits HR acceleration before conditioning can elicit HR deceleration after conditioning. The rabbits' electrocardiograms showed both HR conditioning and HR CRM were correlated with an increased PQ interval--an index of parasympathetic function mediated by the vagus. The data suggest conditioned HR deceleration can generalize from conditioned stimulus to US as a function of conditioning.
条件特异性反射修饰（CRM）描述了在音调与皮肤电刺激配对后单独测试无条件刺激（US）时，家兔（穴兔）瞬膜反应（NMR）的变化。尽管CRM已被重复验证，但尚不清楚它是否发生在NMR之外的反应系统中。作者报告称，家兔心率（HR）的CRM可在心率条件反射后出现。一种在条件反射前引起心率加速的无条件刺激，在条件反射后可引起心率减速。家兔的心电图显示，心率条件反射和心率CRM均与PQ间期延长相关——PQ间期是迷走神经介导的副交感神经功能指标。数据表明，条件性心率减速可作为条件反射的函数，从条件刺激泛化到无条件刺激。
