Trainor Paul A
Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
Semin Cell Dev Biol. 2005 Dec;16(6):683-93. doi: 10.1016/j.semcdb.2005.06.007. Epub 2005 Jul 25.
Of all the model organisms used to study human development, rodents such as mice most accurately reflect human craniofacial development. Collective advances in mouse embryology and mouse genetics continue to shape our understanding of neural crest cell development and by extrapolation the etiology of human congenital head and facial birth defects. The aim of this review is to highlight the considerable progress being made in our understanding of cranial neural crest cell patterning in mouse embryos.
在所有用于研究人类发育的模式生物中，像小鼠这样的啮齿动物最能准确反映人类颅面发育。小鼠胚胎学和小鼠遗传学的共同进展不断塑造着我们对神经嵴细胞发育的理解，并由此推断出人类先天性头面部出生缺陷的病因。这篇综述的目的是强调我们在理解小鼠胚胎中颅神经嵴细胞模式形成方面取得的重大进展。
