Egawa Kiyofumi
Department of Dermatology, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, Japan.
J Dermatol. 2005 May;32(5):381-6. doi: 10.1111/j.1346-8138.2005.tb00911.x.
The treatment of hyperkeratotic palmoplantar eczema is notoriously difficult. A considerable number of patients do not or only partially respond to the current treatments such as topical corticosteroids, topical keratolytics, or PUVA therapy. The purpose of this pilot study was to look for an alternative treatment for hyperkeratotic palmoplantar eczema. We treated five patients with topical vitamin D3 derivatives (calcipotriol 50 microg/g and maxacalcitol 25 microg/g ointments). The lesions almost disappeared after 2 to 8 weeks of treatment in four patients and extremely improved with a seven week treatment in one patient. No adverse effect was observed during or after the treatment, and routine laboratory investigations were within normal ranges. When relapses occurred, they responded well to retreatment. Although the study is preliminary, the results suggest that vitamin D3 derivatives offer a safe, effective alternative form of treatment for recalcitrant hyperkeratotic palmoplantar eczema.
角化过度型掌跖湿疹的治疗 notoriously 困难。相当数量的患者对目前的治疗方法（如外用皮质类固醇、外用角质溶解剂或光化学疗法）没有反应或仅部分有反应。这项初步研究的目的是寻找角化过度型掌跖湿疹的替代治疗方法。我们用外用维生素 D3 衍生物（钙泊三醇 50μg/g 和马沙骨化醇 25μg/g 软膏）治疗了 5 名患者。4 名患者在治疗 2 至 8 周后皮损几乎消失，1 名患者经过 7 周治疗后皮损极大改善。治疗期间及治疗后未观察到不良反应，常规实验室检查结果均在正常范围内。复发时，再次治疗效果良好。尽管该研究是初步的，但结果表明维生素 D3 衍生物为难治性角化过度型掌跖湿疹提供了一种安全、有效的替代治疗方式。
