Yang Min, Chang Jian-Min
Department of Dermatology, Beijing Hospital, Beijing 100730, P.R. China.
Exp Ther Med. 2015 Nov;10(5):1943-1946. doi: 10.3892/etm.2015.2729. Epub 2015 Sep 4.
Chronic hand eczema (CHE) is a common skin disorder with frequent relapses, and its treatment comprises a challenge due to its uncertain etiology. In particular, certain cases of CHE exhibiting severe keratinization have a very poor response to various treatments. The Daivobet ointment, a complex product comprising calcipotriol and betamethasone, has been successfully used for the treatment of patients with plaque-type psoriasis for ~10 years; however, there are few reports on the effect of the ointment on other skin disorders of abnormal keratinization, such as eczema. The present study reported 3 cases of refractory hyperkeratotic eczema of the hand that did not respond to several treatments, but responded well to topical Daivobet treatment.
慢性手部湿疹（CHE）是一种常见的、易复发的皮肤疾病，因其病因不明，其治疗颇具挑战性。特别是某些表现为严重角化的CHE病例，对各种治疗的反应都很差。达力士倍他米松软膏（Daivobet ointment）是一种含有卡泊三醇和倍他米松的复合制剂，已成功用于治疗斑块状银屑病患者约10年；然而，关于该软膏对其他角化异常的皮肤疾病（如湿疹）疗效的报道却很少。本研究报告了3例难治性手部角化过度性湿疹病例，这些病例对多种治疗均无反应，但外用达力士倍他米松治疗效果良好。
