Koebnick C, Wagner K, Garcia A L, Gruendel S, Lahmann P H, Weickert M O, Möhlig M, Harsch I A, Einig C, Speth M, Katz N, Trippo U, Zunft H J F
Dietary Fiber and the Metabolic Syndrome Research Group, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Int J Obes (Lond). 2006 Jul;30(7):1097-103. doi: 10.1038/sj.ijo.0803242. Epub 2006 Feb 14.
Human resistin has been stated to influence preadipocyte cell numbers and to stimulate adipocyte triglyceride lipolysis in vivo and in vitro. However, its role in human obesity remains unclear.
Cross-sectional study for comparisons of lean and obese subjects, and subsequent longitudinal 4-month weight loss intervention study in obese subjects.
Healthy subjects, lean (n=20, BMI<25) and overweight (n=43, BMI>or=25).
Serum resistin, body weight, body fat, waist-to-hip ratio, as well as markers of insulin resistance and lipid metabolism at baseline and after 4 months of intervention.
Serum resistin was positively correlated to HOMA-IR (partial r=0.288; P=0.055), serum fructosamines (partial r=0.280; P=0.062), serum NEFA (partial r=0.276; P=0.066) and negatively to age (partial r=-0.349; P=0.019) and serum apolipoprotein A-1 (partial r=-0.363; P=0.014). During the intervention, serum resistin increased significantly (P<0.001). The increase was inversely related to changes in waist-to-hip ratio (P=0.025) and positively to serum apolipoprotein B (P=0.011). In males only, the increase in resistin during weight loss was predicted by total serum cholesterol at baseline (r=0.703, P=0.007). No relation was observed between changes in resistin and changes in HOMA-IR.
The present study indicates an association between serum resistin and markers of abdominal fat distribution as well as the regulation of lipid metabolism. However, human resistin is unlikely to play an independent role in the regulation of glucose metabolism.
有研究表明，人抵抗素可影响前脂肪细胞数量，并在体内和体外刺激脂肪细胞甘油三酯的脂解作用。然而，其在人类肥胖症中的作用仍不明确。
对瘦人和肥胖受试者进行横断面研究，并对肥胖受试者进行为期4个月的纵向体重减轻干预研究。
健康受试者，瘦人（n = 20，BMI<25）和超重者（n = 43，BMI≥25）。
干预基线及4个月后血清抵抗素、体重、体脂、腰臀比以及胰岛素抵抗和脂质代谢标志物。
血清抵抗素与稳态模型评估的胰岛素抵抗（偏相关系数r = 0.288；P = 0.055）、血清果糖胺（偏相关系数r = 0.280；P = 0.062）、血清非酯化脂肪酸（偏相关系数r = 0.276；P = 0.066）呈正相关，与年龄（偏相关系数r = -0.349；P = 0.019）和血清载脂蛋白A-1（偏相关系数r = -0.363；P = 0.014）呈负相关。在干预期间，血清抵抗素显著升高（P<0.001）。这种升高与腰臀比的变化呈负相关（P = 0.025），与血清载脂蛋白B呈正相关（P = 0.011）。仅在男性中，体重减轻期间抵抗素的升高可由基线时的总血清胆固醇预测（r = 0.703，P = 0.007）。未观察到抵抗素变化与稳态模型评估的胰岛素抵抗变化之间的相关性。
本研究表明血清抵抗素与腹部脂肪分布标志物以及脂质代谢调节之间存在关联。然而，人抵抗素不太可能在葡萄糖代谢调节中发挥独立作用。
