Jancinová V, Nosál R, Petríková M
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Czecho-Slovakia.
Thromb Res. 1992 Jan 1;65(1):1-11. doi: 10.1016/0049-3848(92)90220-5.
A method for the determination of blood platelet aggregability as the function of ADP concentration is described. Individual platelet aggregability was characterised by means of parameters of the sigmoidal relationship between the dose of the aggregating reagent and the aggregation curve amplitude. The method was applied to establish ADP-induced aggregability of various mammalian species. The aggregation curves of rabbit and rat platelets reached significantly lower maximum amplitudes than those of human and dog platelets. The eman concentration of ADP was significantly higher in dog platelets and the slope of the dose-response curve was significantly steeper in rat platelets compared to the other species studied. Some of the causes of individual intra-species ADP-induced aggregation variability revealed by means of dose-response aggregometry are discussed.
描述了一种将血小板聚集性测定为ADP浓度函数的方法。通过聚集试剂剂量与聚集曲线幅度之间的S形关系参数来表征个体血小板聚集性。该方法用于确定各种哺乳动物物种的ADP诱导的聚集性。兔和大鼠血小板的聚集曲线达到的最大幅度明显低于人和狗血小板的聚集曲线。与其他研究物种相比，狗血小板中ADP的释放浓度明显更高，大鼠血小板中剂量反应曲线的斜率明显更陡。讨论了通过剂量反应凝集测定法揭示的物种内个体ADP诱导聚集变异性的一些原因。
