Thompson S G, Vickers M V
Thromb Haemost. 1985 Apr 22;53(2):216-8.
A standardized method for performing dose response platelet aggregation has been developed, and has been used in about 1000 subjects in a large prospective study of ischaemic heart disease. A computer program has been used to fit a sigmoidal relationship between primary aggregation response rate and the log dose of aggregating reagent. Estimates of the parameters of the sigmoid curve are used to characterize an individual's platelet aggregability. Methods for investigating the maintenance of long-term quality control have also been developed.
已经开发出一种用于进行剂量反应血小板聚集的标准化方法，并已在一项关于缺血性心脏病的大型前瞻性研究中应用于约1000名受试者。已使用计算机程序来拟合初级聚集反应率与聚集试剂对数剂量之间的S形关系。S形曲线参数的估计值用于表征个体的血小板聚集能力。还开发了用于研究长期质量控制维持情况的方法。
