Jiang Jiao-Fu, Liu Yong-He, Zhang Chuan-Xing
Department of Clinical Laboratory , Second Xiangya Hospital , Central South University , Changsha 410011, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2005 Jun;30(3):315-7.
To explore the levels of sex hormones in female patients with systemic lupus erythematosus (SLE) and its role in the genesis of SLE.
The serum levels of estradiol, estriol, testosterone, progesterone, and prolactin were determined by electro-chemiluminescence immunoassay in 98 female patients with SLE and compared with those of 38 healthy women.
The serum levels of estradiol, estriol, progesterone, and prolactin were significantly higher than those in the healthy women (P <0.05). The serum levels of estradiol, progesterone, and prolactin in patients with SLE in 25 to 34 year old group were higher than the other age groups and the control group (P < 0.05), and the serum levels of estradiol and prolactin in patients with active phase of SLE were significantly higher than those in patients with stable phase of SLE (P <0.05).
The levels of sex hormones have a close corretation with the genesis and development of SLE.
探讨系统性红斑狼疮（SLE）女性患者性激素水平及其在SLE发病中的作用。
采用电化学发光免疫分析法测定98例SLE女性患者血清雌二醇、雌三醇、睾酮、孕酮和催乳素水平，并与38例健康女性进行比较。
SLE患者血清雌二醇、雌三醇、孕酮和催乳素水平显著高于健康女性（P<0.05）。25至34岁组SLE患者血清雌二醇、孕酮和催乳素水平高于其他年龄组及对照组（P<0.05），SLE活动期患者血清雌二醇和催乳素水平显著高于稳定期患者（P<0.05）。
性激素水平与SLE的发生发展密切相关。
