Lavalle C, Loyo E, Paniagua R, Bermudez J A, Herrera J, Graef A, Gonzalez-Barcena D, Fraga A
J Rheumatol. 1987 Apr;14(2):268-72.
The hypothalamic-pituitary-gonadal axis was studied in 8 male patients with systemic lupus erythematosus (SLE), both before and after intravenous administration of luteinizing hormone-releasing hormone (LH-RH). We provide evidence herein that resting serum levels of estrone are increased and that resting serum testosterone (T) and dihydrotestosterone (DHT) levels are decreased in male patients with SLE. The decreased serum T levels were observed even after the IV administration of 25 micrograms of LH-RH. The high basal serum prolactin (PRL) levels observed in these patients with SLE is a novel finding not previously reported that could explain why serum T and DHT levels are low in this syndrome. We observed a decrease in the pituitary response to LH-RH stimulation; this low response could also be a hormonal manifestation of hyperprolactinemia. Furthermore, it has been suggested that PRL plays a role in immunocompetence, and therefore it could have influence either directly or indirectly in the altered immunoregulation observed in SLE.
对8名男性系统性红斑狼疮（SLE）患者在静脉注射促黄体生成素释放激素（LH-RH）前后的下丘脑-垂体-性腺轴进行了研究。我们在此提供证据表明，男性SLE患者静息血清雌酮水平升高，静息血清睾酮（T）和双氢睾酮（DHT）水平降低。即使静脉注射25微克LH-RH后，血清T水平仍降低。在这些SLE患者中观察到的高基础血清催乳素（PRL）水平是此前未报道的新发现，这可以解释该综合征中血清T和DHT水平为何较低。我们观察到垂体对LH-RH刺激的反应降低；这种低反应也可能是高催乳素血症的一种激素表现。此外，有人提出PRL在免疫能力中起作用，因此它可能直接或间接影响SLE中观察到的免疫调节改变。
