病毒致病机制中的树突状细胞：具有保护作用还是存在缺陷？
Dendritic cells in viral pathogenesis: protective or defective?
作者信息
Pollara Gabriele, Kwan Antonia, Newton Philippa J, Handley Matthew E, Chain Benjamin M, Katz David R
机构信息
Department of Immunology and Molecular Pathology, University College London, Windeyer Institute of Medical Sciences, London W1T 4JF, UK.
出版信息
Int J Exp Pathol. 2005 Aug;86(4):187-204. doi: 10.1111/j.0959-9673.2005.00440.x.
Dendritic cells (DC) are potent antigen-presenting cells that are critical in the initiation of immune responses to control and/or eliminate viral infections. Recent studies have investigated the effects of virus infection on the biology of DC. This review summarizes these changes, focusing on both the DC parameters affected and the viral factors involved. In addition, the central role of DC biology in the pathogenesis of several viral families, including herpesviruses, paramyxoviruses and retroviruses, is explored. The field of pathogen recognition by DC is addressed, focusing on its role in protecting the host from viral infection, as well as the ability of viruses to exploit such host receptor ligation and signalling to their replicative advantage. The hypothesis is proposed that virus and host have evolved a symbiotic relationship to ensure both viral transmission and host survival.
树突状细胞（DC）是强大的抗原呈递细胞，在启动免疫反应以控制和/或消除病毒感染方面至关重要。最近的研究调查了病毒感染对DC生物学特性的影响。本综述总结了这些变化，重点关注受影响的DC参数和涉及的病毒因素。此外，还探讨了DC生物学特性在包括疱疹病毒、副粘病毒和逆转录病毒在内的几个病毒家族发病机制中的核心作用。本文讨论了DC识别病原体的领域，重点关注其在保护宿主免受病毒感染中的作用，以及病毒利用这种宿主受体连接和信号传导以获得复制优势的能力。本文提出了一个假说，即病毒与宿主已经进化出一种共生关系，以确保病毒传播和宿主存活。
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