Lateo S, Charlton F, Hudson M, Lawrence C M
Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
Clin Exp Dermatol. 2005 Sep;30(5):484-6. doi: 10.1111/j.1365-2230.2005.01793.x.
Ectopic calcification following liver transplantation has been reported to occur in various internal organs but there have been few reports of skin involvement. The pathogenesis is uncertain with previous reports suggesting that the calcifications could be either dystrophic or metastatic. The large amount of intravenous calcium needed to correct hypocalcaemia secondary to blood product transfusion is thought to play a central role. We report a case of calcinosis cutis developing after liver transplantation in a 22-year-old woman at sites where no intravenous calcium had been administered. In previously published cases serum calcium and phosphate levels were reported as normal. In our case serum calcium levels were also within or below normal limits with the exception of a transient rise in the immediate post-operative period. Our case supports earlier hypotheses that short-lived and often undetected elevations in the calcium-phosphate product are implicated in this condition.
肝移植后异位钙化已被报道发生于各种内脏器官，但皮肤受累的报道较少。其发病机制尚不确定，先前的报道表明钙化可能是营养不良性或转移性的。纠正输血后继发性低钙血症所需的大量静脉补钙被认为起核心作用。我们报告一例22岁女性肝移植后发生皮肤钙化的病例，钙化部位未进行过静脉补钙。在先前发表的病例中，血清钙和磷水平报告为正常。在我们的病例中，除术后即刻有短暂升高外，血清钙水平也在正常范围内或低于正常范围。我们的病例支持了早期的假说，即钙磷乘积的短暂且常未被检测到的升高与这种情况有关。
