Hung Iou-Jih, Lin Jainn-Jim, Yang Chao-Ping, Hsueh Chuen
Department of Medicine, Division of Hematology/Oncology, Chang Gung Children's Hospital, Chang Gung University, Taoyuan, Taiwan.
Pediatr Blood Cancer. 2006 Oct 15;47(5):616-20. doi: 10.1002/pbc.20499.
We report two cases of intrathoracic Castleman disease presenting with paraneoplastic syndrome. Patient 1 was a 10-year-old girl with short stature. She was found to have delayed bone age, slow growth velocity, and iron-deficiency anemia, which was refractory to treatment. Thrombocytosis and hypergammaglobulinemia were later detected. Chest X-ray revealed a hilar mass. Patient 2 was a 14-year-old boy who had severe cough, progressive mucocutaneous erosion, and dermatitis. Chest X-ray showed a mediastinal mass. Sections of skin biopsy showed findings consistent with pemphigus disease. In each case, the histological diagnosis of Castleman disease was made.
我们报告两例伴有副肿瘤综合征的胸内型Castleman病。病例1是一名身材矮小的10岁女孩。她被发现骨龄延迟、生长速度缓慢以及患有缺铁性贫血，且对治疗无效。后来检测到血小板增多症和高球蛋白血症。胸部X线显示肺门肿块。病例2是一名14岁男孩，有严重咳嗽、进行性黏膜皮肤糜烂和皮炎。胸部X线显示纵隔肿块。皮肤活检切片显示的结果与天疱疮疾病相符。在每个病例中，均做出了Castleman病的组织学诊断。
