Andersen C, Clemensen S E, Henneberg S W, Hansen H S, Nielsen J S, Hole P
Odense Sygehus, Anaestesiologisk/intensiv afdeling V og medicinsk afdeling B.
Ugeskr Laeger. 1992 Apr 20;154(17):1176-9.
Thirty patients who had severe incapacitating angina pectoris which had not reacted to the conventional therapeutic measures and which required massive daily opioid consumption were treated with electrical spinal cord stimulation (SCS) by means of a completely implantable stimulation system. The therapeutic effect was good in 87% of the patients who experienced considerably reduced frequency of attacks and markedly reduced opioid consumption (p less than 0.00005). Nine of the patients could reduce opioid consumption and 14 out of 27 could cease their otherwise daily opioid consumption. In four patients, the therapeutic effect was unsatisfactory. In the first 22 patients in whom a unipolar electrode was introduced, displacement of the electrode and subsequent reoperation was a frequent problem. This problem disappeared after change to multipolar electrodes as slight changes in placing of the electrode could easily be compensated for via the external programming equipment. This investigation reveals that SCS is a good therapeutic alternative for this selected patient category.
30例患有严重致残性心绞痛且对传统治疗措施无反应、每天需要大量使用阿片类药物的患者，采用完全植入式刺激系统进行脊髓电刺激（SCS）治疗。87%的患者治疗效果良好，发作频率显著降低，阿片类药物消耗量明显减少（p<0.00005）。9例患者能够减少阿片类药物的消耗量，27例中有14例能够停止每日使用阿片类药物。4例患者治疗效果不理想。在最初引入单极电极的22例患者中，电极移位及随后的再次手术是常见问题。改用多极电极后，这个问题消失了，因为电极位置的轻微变化可以通过外部编程设备轻松补偿。这项研究表明，SCS是这类特定患者群体的一种良好治疗选择。
