使用1,2-二氢咪唑并[1,2-a]喹啉对映选择性酰化催化剂对醇进行动力学拆分
Kinetic resolution of alcohols using a 1,2-dihydroimidazo[1,2-a]quinoline enantioselective acylation catalyst.
作者信息
Birman Vladimir B, Jiang Hui
机构信息
Department of Chemistry, Washington University, Campus Box 1134, One Brookings Drive, St. Louis, MO 63130, USA.
出版信息
Org Lett. 2005 Aug 4;7(16):3445-7. doi: 10.1021/ol051063v.
PMID:16048313
Abstract
A new enantioselective acylation catalyst (Cl-PIQ), designed to provide enhanced pi-stacking with benzylic and cinnamyl alcohol substrates, was found to give considerably increased reaction rates and selectivities compared with the first-generation catalyst CF(3)-PIP. [reaction: see text]
摘要
一种新的对映选择性酰化催化剂（Cl-PIQ），其设计目的是增强与苄醇和肉桂醇底物的π-堆积作用，结果发现与第一代催化剂CF(3)-PIP相比，该催化剂能显著提高反应速率和选择性。[反应：见正文]
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