Takahashi Hidetoshi, Iwase Masao, Nakahachi Takayuki, Sekiyama Ryuji, Tabushi Kaoru, Kajimoto Osami, Shimizu Akira, Takeda Masatoshi
Osaka University Graduate School of Medicine, Course of Advanced Medicine, Department of Post-Genomics and Diseases, Division of Psychiatry and Behavioral Proteomics, Suita, Japan.
Psychiatry Clin Neurosci. 2005 Aug;59(4):453-60. doi: 10.1111/j.1440-1819.2005.01398.x.
Both spatial working memory deficit and disorganization symptoms have been considered significant components of schizophrenic impairment involved with the dorsolateral prefrontal cortex. The purpose of the present study was to investigate the relationships among spatial working memory, psychiatric symptoms including disorganization symptoms, and social functioning in schizophrenia. Fifty clinically stable patients with schizophrenia and 34 healthy controls participated in the study. Patients were rated with the Brief Psychiatric Rating Scale and the Rehabilitation Evaluation Hall and Baker. The Advanced Trail Making Test was used to evaluate spatial working memory. Patients demonstrated significantly reduced spatial working memory compared to that of healthy controls. Spatial working memory in patients correlated significantly with social functioning such as self-care skills, community skills and speech disturbance, and with disorganization symptoms. Disorganization symptoms also correlated with these aspects of social functioning. In conclusion it is suggested that both spatial working memory deficit and disorganization symptoms, which are impairments involved with the dorsolateral prefrontal cortex dysfunction, can serve as effective predictors of social functioning.
空间工作记忆缺陷和紊乱症状都被认为是与背外侧前额叶皮层相关的精神分裂症损伤的重要组成部分。本研究的目的是调查精神分裂症患者的空间工作记忆、包括紊乱症状在内的精神症状以及社会功能之间的关系。50名临床稳定的精神分裂症患者和34名健康对照者参与了该研究。使用简明精神病评定量表以及康复评估霍尔和贝克量表对患者进行评分。采用高级连线测验来评估空间工作记忆。与健康对照者相比，患者的空间工作记忆显著降低。患者的空间工作记忆与自我护理技能、社区技能和言语障碍等社会功能以及紊乱症状显著相关。紊乱症状也与社会功能的这些方面相关。总之，研究表明，作为与背外侧前额叶皮层功能障碍相关的损伤，空间工作记忆缺陷和紊乱症状都可作为社会功能的有效预测指标。
