Giugliano Emilio, Cagnazzo Elisa, Pansini Giancarlo, Vesce Fortunato, Marci Roberto
Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Ferrara, Italy.
Clin Exp Reprod Med. 2013 Mar;40(1):38-41. doi: 10.5653/cerm.2013.40.1.38. Epub 2013 Mar 31.
Liver damage induced by ovarian stimulation has been demonstrated in some cases reported in the literature. However, there has never been a fruitful debate on this topic. The present manuscript tried to fill this gap. We reported a case of a 35-year-old nulliparous woman admitted to our obstetric emergency room for severe pre-eclampsia. She had been subjected to four cycles of controlled ovarian stimulation for intrauterine insemination. At 32 weeks of gestation, she developed severe pre-eclampsia, which led to HELLP syndrome complicated by fatal liver failure. The etiological link between ovarian stimulation and HELLP syndrome is intriguing. Further investigations are needed to understand whether repeated ovarian stimulation may represent a risk factor in pre-eclamptic patients.
文献报道的一些病例已证实卵巢刺激会导致肝损伤。然而，关于这一话题从未有过富有成效的讨论。本手稿试图填补这一空白。我们报告了一例35岁未生育女性，因重度子痫前期入住我们的产科急诊室。她曾接受四个周期的控制性卵巢刺激以进行宫内人工授精。妊娠32周时，她出现重度子痫前期，进而发展为伴有致命肝衰竭的HELLP综合征。卵巢刺激与HELLP综合征之间的病因联系很有趣。需要进一步研究以了解反复卵巢刺激是否可能是子痫前期患者的一个危险因素。
