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本文引用的文献

1
Evidence for biliary excretion of vancomycin into stool during intravenous therapy: potential implications for rectal colonization with vancomycin-resistant enterococci.静脉治疗期间万古霉素经胆汁排泄至粪便的证据：对耐万古霉素肠球菌直肠定植的潜在影响。
Antimicrob Agents Chemother. 2004 Nov;48(11):4427-9. doi: 10.1128/AAC.48.11.4427-4429.2004.
2
Oral administration of beta-lactamase preserves colonization resistance of piperacillin-treated mice.口服β-内酰胺酶可维持哌拉西林治疗小鼠的定植抗性。
J Infect Dis. 2003 Nov 15;188(10):1605-9. doi: 10.1086/379153. Epub 2003 Oct 23.
3
Effect of parenteral antibiotic administration on establishment of intestinal colonization in mice by Klebsiella pneumoniae strains producing extended-spectrum beta-lactamases.肠道外给予抗生素对产超广谱β-内酰胺酶的肺炎克雷伯菌菌株在小鼠肠道定植的影响。
Antimicrob Agents Chemother. 2003 Nov;47(11):3610-2. doi: 10.1128/AAC.47.11.3610-3612.2003.
4
Some laboratory and clinical experiences with a new antibiotic, vancomycin.一种新型抗生素——万古霉素的一些实验室及临床经验
Proc Staff Meet Mayo Clin. 1956 Oct 17;31(21):564-82.
5
Quinupristin-dalfopristin and linezolid: evidence and opinion.奎奴普丁-达福普汀与利奈唑胺：证据与观点。
Clin Infect Dis. 2003 Feb 15;36(4):473-81. doi: 10.1086/367662. Epub 2003 Jan 31.
6
Effects of antibiotics on nosocomial epidemiology of vancomycin-resistant enterococci.抗生素对耐万古霉素肠球菌医院感染流行病学的影响。
Antimicrob Agents Chemother. 2002 Jun;46(6):1619-28. doi: 10.1128/AAC.46.6.1619-1628.2002.
7
Effect of antimicrobial agents on the ecological balance of human microflora.抗菌药物对人体微生物群落生态平衡的影响。
Lancet Infect Dis. 2001 Sep;1(2):101-14. doi: 10.1016/S1473-3099(01)00066-4.
8
Ecological effects of linezolid versus amoxicillin/clavulanic acid on the normal intestinal microflora.利奈唑胺与阿莫西林/克拉维酸对正常肠道微生物群的生态效应。
Scand J Infect Dis. 2001;33(12):899-903. doi: 10.1080/00365540110076714.
9
In vitro activities of daptomycin against 2,789 clinical isolates from 11 North American medical centers.达托霉素对来自11个北美医疗中心的2789株临床分离株的体外活性。
Antimicrob Agents Chemother. 2001 Jun;45(6):1919-22. doi: 10.1128/AAC.45.6.1919-1922.2001.
10
Effect of antibiotic therapy on the density of vancomycin-resistant enterococci in the stool of colonized patients.抗生素治疗对定植患者粪便中耐万古霉素肠球菌密度的影响。
N Engl J Med. 2000 Dec 28;343(26):1925-32. doi: 10.1056/NEJM200012283432604.

达托霉素、利奈唑胺和万古霉素对小鼠肠道中耐万古霉素肠球菌和产超广谱β-内酰胺酶肺炎克雷伯菌定植的影响。

Effects of daptomycin, linezolid, and vancomycin on establishment of intestinal colonization with vancomycin-resistant enterococci and extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae in mice.

作者信息

Pultz Nicole J, Stiefel Usha, Donskey Curtis J

机构信息

Infectious Diseases Section (111 W), Louis Stokes Cleveland VA Medical Center, 10701 East Blvd., Cleveland, Ohio 44106, USA.

出版信息

Antimicrob Agents Chemother. 2005 Aug;49(8):3513-6. doi: 10.1128/AAC.49.8.3513-3516.2005.

DOI:10.1128/AAC.49.8.3513-3516.2005
PMID:16048971
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1196280/
Abstract

In mice, vancomycin and linezolid treatment disrupted the anaerobic intestinal microflora, based on denaturing gradient gel electrophoresis analysis, and promoted colonization by Klebsiella pneumoniae and vancomycin-resistant enterococci. However, the effects varied depending on dose and duration of treatment. Daptomycin treatment did not disrupt the anaerobic microflora or promote either pathogen.

摘要

基于变性梯度凝胶电泳分析，在小鼠中，万古霉素和利奈唑胺治疗破坏了肠道厌氧微生物群，并促进了肺炎克雷伯菌和耐万古霉素肠球菌的定植。然而，其效果因治疗剂量和持续时间而异。达托霉素治疗并未破坏厌氧微生物群，也未促进任何一种病原体的生长。