达托霉素、利奈唑胺和万古霉素对小鼠肠道中耐万古霉素肠球菌和产超广谱β-内酰胺酶肺炎克雷伯菌定植的影响。
Effects of daptomycin, linezolid, and vancomycin on establishment of intestinal colonization with vancomycin-resistant enterococci and extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae in mice.
作者信息
Pultz Nicole J, Stiefel Usha, Donskey Curtis J
机构信息
Infectious Diseases Section (111 W), Louis Stokes Cleveland VA Medical Center, 10701 East Blvd., Cleveland, Ohio 44106, USA.
出版信息
Antimicrob Agents Chemother. 2005 Aug;49(8):3513-6. doi: 10.1128/AAC.49.8.3513-3516.2005.
Abstract
In mice, vancomycin and linezolid treatment disrupted the anaerobic intestinal microflora, based on denaturing gradient gel electrophoresis analysis, and promoted colonization by Klebsiella pneumoniae and vancomycin-resistant enterococci. However, the effects varied depending on dose and duration of treatment. Daptomycin treatment did not disrupt the anaerobic microflora or promote either pathogen.
摘要
基于变性梯度凝胶电泳分析，在小鼠中，万古霉素和利奈唑胺治疗破坏了肠道厌氧微生物群，并促进了肺炎克雷伯菌和耐万古霉素肠球菌的定植。然而，其效果因治疗剂量和持续时间而异。达托霉素治疗并未破坏厌氧微生物群，也未促进任何一种病原体的生长。
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