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Bowel colonization with vancomycin-resistant enterococci after antimicrobial therapy for intra-abdominal infections: observations from 2 randomized comparative clinical trials of ertapenem therapy.腹腔内感染抗菌治疗后耐万古霉素肠球菌的肠道定植：厄他培南治疗两项随机对照临床试验的观察结果
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Effects of imipenem-cilastatin, ertapenem, piperacillin-tazobactam, and ceftriaxone treatments on persistence of intestinal colonization by extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae strains in mice.亚胺培南-西司他丁、厄他培南、哌拉西林-他唑巴坦及头孢曲松治疗对产超广谱β-内酰胺酶肺炎克雷伯菌菌株在小鼠肠道定植持续性的影响
Antimicrob Agents Chemother. 2007 Aug;51(8):3044-5. doi: 10.1128/AAC.00194-07. Epub 2007 Jun 11.

本文引用的文献

1
Bowel colonization with resistant gram-negative bacilli after antimicrobial therapy of intra-abdominal infections: observations from two randomized comparative clinical trials of ertapenem therapy.腹腔内感染抗菌治疗后耐药革兰氏阴性杆菌的肠道定植：厄他培南治疗两项随机对照临床试验的观察结果
Eur J Clin Microbiol Infect Dis. 2005 Jul;24(7):443-9. doi: 10.1007/s10096-005-1356-0.
2
Ertapenem pharmacokinetics and impact on intestinal microflora, in comparison to those of ceftriaxone, after multiple dosing in male and female volunteers.在男性和女性志愿者多次给药后，与头孢曲松相比，厄他培南的药代动力学及其对肠道微生物群的影响。
Antimicrob Agents Chemother. 2004 Oct;48(10):3765-72. doi: 10.1128/AAC.48.10.3765-3772.2004.
3
The role of the intestinal tract as a reservoir and source for transmission of nosocomial pathogens.肠道作为医院感染病原体储存库和传播源的作用。
Clin Infect Dis. 2004 Jul 15;39(2):219-26. doi: 10.1086/422002. Epub 2004 Jun 25.
4
Effect of parenteral antibiotic administration on establishment of intestinal colonization in mice by Klebsiella pneumoniae strains producing extended-spectrum beta-lactamases.肠道外给予抗生素对产超广谱β-内酰胺酶的肺炎克雷伯菌菌株在小鼠肠道定植的影响。
Antimicrob Agents Chemother. 2003 Nov;47(11):3610-2. doi: 10.1128/AAC.47.11.3610-3612.2003.
5
Effect of antimicrobial agents on the ecological balance of human microflora.抗菌药物对人体微生物群落生态平衡的影响。
Lancet Infect Dis. 2001 Sep;1(2):101-14. doi: 10.1016/S1473-3099(01)00066-4.
6
Effect of parenteral antibiotic administration on persistence of vancomycin-resistant Enterococcus faecium in the mouse gastrointestinal tract.肠外给予抗生素对万古霉素耐药屎肠球菌在小鼠胃肠道中持续存在的影响。
J Infect Dis. 1999 Aug;180(2):384-90. doi: 10.1086/314874.
7
Effect of imipenem/cilastatin on the colonic microflora.亚胺培南/西司他丁对结肠微生物群的影响。
Rev Infect Dis. 1985 Jul-Aug;7 Suppl 3:S432-4. doi: 10.1093/clinids/7.supplement_3.s432.
8
Impact of imipenem/cilastatin therapy on normal fecal flora.亚胺培南/西司他丁疗法对正常粪便菌群的影响。
Am J Med. 1985 Jun 7;78(6A):41-6. doi: 10.1016/0002-9343(85)90100-7.
9
Effect of meropenem on the intestinal microflora.美罗培南对肠道微生物群的影响。
Eur J Clin Microbiol Infect Dis. 1991 Jun;10(6):524-7. doi: 10.1007/BF01963943.

碳青霉烯类药物给药对小鼠体内耐万古霉素肠球菌和肺炎克雷伯菌肠道定植的影响。

Effect of carbapenem administration on establishment of intestinal colonization by vancomycin-resistant enterococci and Klebsiella pneumoniae in mice.

作者信息

Stiefel Usha, Pultz Nicole J, Donskey Curtis J

机构信息

Infectious Diseases Section (111 W), Louis Stokes Cleveland Department of VA Medical Center, 10701 East Blvd., Cleveland, OH 44106, USA.

出版信息

Antimicrob Agents Chemother. 2007 Jan;51(1):372-5. doi: 10.1128/AAC.00355-06. Epub 2006 Oct 16.

DOI:10.1128/AAC.00355-06
PMID:17043115
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1797675/
Abstract

In a mouse model, ertapenem inhibited the anaerobic intestinal microflora and promoted overgrowth of enterococci, whereas imipenem-cilastatin had no effect on the indigenous microflora. Ertapenem, but not imipenem-cilastatin, promoted modest overgrowth of vancomycin-resistant enterococci when exposure occurred during treatment. Neither agent promoted colonization with extended-spectrum beta-lactamase-producing Klebsiella pneumoniae.

摘要

在小鼠模型中，厄他培南抑制肠道厌氧微生物群并促进肠球菌过度生长，而亚胺培南 - 西司他丁对原生微生物群无影响。在治疗期间暴露时，厄他培南而非亚胺培南 - 西司他丁会促进耐万古霉素肠球菌适度过度生长。两种药物均未促进产超广谱β-内酰胺酶的肺炎克雷伯菌的定植。