碳青霉烯类药物给药对小鼠体内耐万古霉素肠球菌和肺炎克雷伯菌肠道定植的影响。
Effect of carbapenem administration on establishment of intestinal colonization by vancomycin-resistant enterococci and Klebsiella pneumoniae in mice.
作者信息
Stiefel Usha, Pultz Nicole J, Donskey Curtis J
机构信息
Infectious Diseases Section (111 W), Louis Stokes Cleveland Department of VA Medical Center, 10701 East Blvd., Cleveland, OH 44106, USA.
出版信息
Antimicrob Agents Chemother. 2007 Jan;51(1):372-5. doi: 10.1128/AAC.00355-06. Epub 2006 Oct 16.
Abstract
In a mouse model, ertapenem inhibited the anaerobic intestinal microflora and promoted overgrowth of enterococci, whereas imipenem-cilastatin had no effect on the indigenous microflora. Ertapenem, but not imipenem-cilastatin, promoted modest overgrowth of vancomycin-resistant enterococci when exposure occurred during treatment. Neither agent promoted colonization with extended-spectrum beta-lactamase-producing Klebsiella pneumoniae.
摘要
在小鼠模型中，厄他培南抑制肠道厌氧微生物群并促进肠球菌过度生长，而亚胺培南 - 西司他丁对原生微生物群无影响。在治疗期间暴露时，厄他培南而非亚胺培南 - 西司他丁会促进耐万古霉素肠球菌适度过度生长。两种药物均未促进产超广谱β-内酰胺酶的肺炎克雷伯菌的定植。
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