Annesini M C, Di Paola L, Marrelli L, Piemonte V, Turchetti L
Department of Chemical Engineering, University of Rome La Sapienza, Rome, Italy.
Int J Artif Organs. 2005 Jul;28(7):686-93. doi: 10.1177/039139880502800707.
Adsorption equilibrium of bilirubin onto polymeric resins is studied. Solutions containing albumin are used in order to simulate the behavior of systems for removal of albumin-bound substances from blood, serum or dialysis fluids. The effect of albumin pre-loading on the resin is also analysed. Results are explained by a chemically based model that accounts for binding reaction between albumin and bilirubin in the liquid phase. Thermodynamic equilibria and physical models are essential tools for designing adsorption columns aimed at detoxification treatments.
研究了胆红素在聚合树脂上的吸附平衡。使用含有白蛋白的溶液来模拟从血液、血清或透析液中去除与白蛋白结合物质的系统行为。还分析了白蛋白预负载对树脂的影响。结果通过基于化学的模型进行解释，该模型考虑了液相中白蛋白和胆红素之间的结合反应。热力学平衡和物理模型是设计用于解毒治疗的吸附柱的重要工具。
