Treves T A, Verchovsky R, Klimovitzky S, Korczyn A D
Department of Neurology, Rabin Medical Center, Petah Tikva 49100, Israel.
Int Psychogeriatr. 2005 Jun;17(2):265-73. doi: 10.1017/s1041610205001596.
The risk of developing dementia by elderly patients with only subjective memory complaints (SMC) is unclear. Our objective was to assess the prognosis of such patients regarding subsequent development of dementia.
From 1992 to 1996, 211 consecutive patients (age 67.4 +/- 9.4 years, mean +/- SD) were diagnosed as having SMC. These patients were followed for 3 years or to the time they were diagnosed with dementia, whichever came first. A survival analysis was performed for occurrence of dementia within 3 years.
The duration of memory decline was shorter among patients who developed dementia than among those who did not (32.6 vs. 49.9 months, F = 3.3, p = 0.07). Patients who developed dementia tended to be older at the reported onset of memory decline (71 vs. 66.2 years, F = 3.2, p = 0.07). Lower risk of dementia was associated with higher cognitive performance at entry [odds ratio (OR) = 0.74 (0.59-0.92)] and longer time from onset of memory decline to referral [OR = 0.91 (0.85-0.98)].
Subjects with SMC have an increased risk of developing dementia, particularly those with lower cognitive status at entry and with older age at onset of memory complaints, and shorter duration of their memory complaints.
仅有主观记忆障碍（SMC）的老年患者患痴呆症的风险尚不清楚。我们的目的是评估这类患者随后发生痴呆症的预后情况。
1992年至1996年，连续211例患者（年龄67.4±9.4岁，均值±标准差）被诊断为患有SMC。对这些患者进行了3年的随访，或直至他们被诊断为痴呆症，以先发生者为准。对3年内痴呆症的发生情况进行了生存分析。
发生痴呆症的患者记忆衰退持续时间比未发生痴呆症的患者短（32.6个月对49.9个月，F = 3.3，p = 0.07）。发生痴呆症的患者在报告的记忆衰退开始时往往年龄更大（71岁对66.2岁，F = 3.2，p = 0.07）。痴呆症风险较低与入组时较高的认知表现相关[比值比（OR）= 0.74（0.59 - 0.92）]，以及从记忆衰退开始到转诊的时间较长[OR = 0.91（0.85 - 0.98）]。
患有SMC的受试者患痴呆症的风险增加，尤其是那些入组时认知状态较低、记忆障碍开始时年龄较大且记忆障碍持续时间较短的受试者。
