Turatti Eveline, da Costa Neves Adriana, de Magalhães Marina Helena Cury Gallottini, de Sousa Suzana Orsini Machado
Department of Oral Pathology, University of Fortaleza, Brazil.
J Oral Sci. 2005 Jun;47(2):71-6. doi: 10.2334/josnusd.47.71.
Some oral cancers are known to develop from dysplastic oral epithelium. In the present study, the expression of c-Jun, c-Fos, and cyclin D1 proteins in oral epithelial lesions with different degrees of dysplasia, and in oral squamous cell carcinomas (OSCCs) was evaluated. Eighteen cases of mild dysplasia, 23 cases of moderate to severe dysplasia and 24 OSCCs were studied immunohistochemically. Additionally, 15 sections of oral mucosa without any evidence of dysplasia were included in the study.
c-Jun expression increased according to the degree of oral dysplasia, with the greatest expression found in OSCC. c-Fos expression was intense in normal mucosa, reduced in mild dysplasia and high in moderate to severe dysplasia and in OSCCs. Cyclin D1 was expressed in only a few cases of moderate to severe dysplasia and in most of the OSCCs. Statistical analysis showed a correlation between the three proteins and the degree of epithelial alteration. The present results indicate a possible role of c-Jun and c-Fos in malignant transformation of oral mucosa.
已知一些口腔癌由发育异常的口腔上皮发展而来。在本研究中，评估了不同程度发育异常的口腔上皮病变以及口腔鳞状细胞癌（OSCC）中c-Jun、c-Fos和细胞周期蛋白D1蛋白的表达。对18例轻度发育异常、23例中重度发育异常和24例OSCC进行了免疫组织化学研究。此外，15例无发育异常迹象的口腔黏膜切片也纳入了研究。
c-Jun表达随口腔发育异常程度增加而升高，在OSCC中表达最高。c-Fos在正常黏膜中表达强烈，在轻度发育异常中降低，在中重度发育异常和OSCC中升高。细胞周期蛋白D1仅在少数中重度发育异常病例和大多数OSCC中表达。统计分析表明这三种蛋白与上皮改变程度之间存在相关性。目前的结果表明c-Jun和c-Fos在口腔黏膜恶性转化中可能起作用。
