Reiss A L, Freund L
Behavioral Genetics and Neuroimaging Research Center, Kennedy Institute, Baltimore, MD.
Am J Med Genet. 1992;43(1-2):35-46. doi: 10.1002/ajmg.1320430106.
Comparison of 34 fragile X [(fra(X)] male children (age 3-18 years) with 32 IQ- and age-matched, non-fra(X) male control children was conducted using specific DSM-III-R criteria for autism. Statistical analyses supported predictions that fra(X) males show increased dysfunction in peer social play, nonverbal communication (e.g., gaze aversion, gesturing), verbal communication (e.g., rate, volume, word/phrase perseveration), and repetitive motor behaviors (e.g., handflapping, rocking). There was a trend for fra(X) children to show abnormal responsivity to sensory stimuli as well such as oversensitivity to sound and increased mouthing or smelling of objects. The investigation supports the contention that fra(X) males manifest a specific subset of behaviors from the autistic spectrum. Implications for treatment are discussed.
采用针对自闭症的特定《精神疾病诊断与统计手册》第三版修订版（DSM-III-R）标准，对34名脆性X综合征[（fra(X)）]男童（年龄3至18岁）与32名智商和年龄匹配的非fra(X)男性对照儿童进行了比较。统计分析支持了以下预测：fra(X)男性在同伴社交游戏、非语言交流（如目光回避、手势）、语言交流（如语速、音量、单词/短语重复）以及重复运动行为（如拍手、摇晃身体）方面表现出更多功能障碍。fra(X)儿童也有对感觉刺激反应异常的趋势，比如对声音过度敏感以及增加对物体的舔咬或嗅闻行为。该调查支持了fra(X)男性表现出自闭症谱系中特定行为子集的观点。文中还讨论了其对治疗的启示。
