Reiss A L, Freund L
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD.
J Am Acad Child Adolesc Psychiatry. 1990 Nov;29(6):885-91. doi: 10.1097/00004583-199011000-00007.
Although reports of autistic behavior in fragile X males have been published for 8 years, there is little information about specific behaviors shown by fragile X males that are suggestive of the diagnosis of autism. The new diagnostic criteria for autistic disorder contained in the DSM-III-R provided the opportunity for more closely investigating the topography of autistic behavior in 17 fragile X males and the effects of age and IQ on its occurrence. The criteria most frequently met by these subjects were related to deficits in social interaction with peers, abnormalities in verbal and nonverbal communication, stereotypic motor behavior, and unusual responses to sensory stimuli. Fragile X subjects did not frequently show abnormalities in attachment behaviors and reciprocal interaction with caregivers. There were no discernable age or IQ effects. The importance and implications of these findings are discussed and the need for greater exploration of autism "subtypes" is emphasized.
尽管关于脆性X综合征男性自闭症行为的报告已发表8年，但关于脆性X综合征男性所表现出的提示自闭症诊断的特定行为的信息却很少。《精神疾病诊断与统计手册第三版修订本》（DSM-III-R）中自闭症障碍的新诊断标准为更深入研究17名脆性X综合征男性的自闭症行为特征以及年龄和智商对其发生的影响提供了契机。这些受试者最常符合的标准与同龄人社交互动缺陷、言语和非言语交流异常、刻板运动行为以及对感觉刺激的异常反应有关。脆性X综合征受试者在依恋行为和与照顾者的相互互动中并不常表现出异常。未发现明显的年龄或智商影响。讨论了这些发现的重要性和意义，并强调了进一步探索自闭症“亚型”的必要性。
