Lafeber F P, van der Kraan P M, van Roy H L, Vitters E L, Huber-Bruning O, van den Berg W B, Bijlsma J W
Department of Rheumatology, University Hospital Utrecht, The Netherlands.
Am J Pathol. 1992 Jun;140(6):1421-9.
Proteoglycan synthesis of mild-to-moderate osteoarthritic human knee cartilage was compared with that of normal cartilage of the same donor. Immediately after cartilage was obtained, the synthesis rate of proteoglycans was higher for osteoarthritic cartilage than for normal cartilage. Proteoglycan synthesis was then located, for both normal and osteoarthritic cartilage, in the middle and deep zone. However, after 4 days of culture, proteoglycan synthesis rate was higher for normal cartilage than for osteoarthritic cartilage. The reason for this transition from a lower to a higher proteoglycan synthesis rate was a strong increase in the proteoglycan synthesis in the superficial zone of normal cartilage. This was not observed for the osteoarthritic cartilage. The chondrocytes in the superficial zone of osteoarthritic cartilage, in contrast to normal cartilage, were mainly joined in cell clusters and proliferating. This may explain their inability to contribute to proteoglycan synthesis.
将轻度至中度骨关节炎患者膝关节软骨的蛋白聚糖合成与同一供体的正常软骨进行了比较。软骨获取后，立即发现骨关节炎软骨的蛋白聚糖合成速率高于正常软骨。随后发现，正常软骨和骨关节炎软骨的蛋白聚糖合成均位于中层和深层。然而，培养4天后，正常软骨的蛋白聚糖合成速率高于骨关节炎软骨。蛋白聚糖合成速率从较低转变为较高的原因是正常软骨表层区域的蛋白聚糖合成大幅增加。骨关节炎软骨未观察到这种情况。与正常软骨相比，骨关节炎软骨表层区域的软骨细胞主要聚集成细胞簇并增殖。这可能解释了它们无法促进蛋白聚糖合成的原因。
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