Barraza-Villarreal Albino, Farías Paulina, Díaz Sánchez Vicente, Bailey Janice L, De Jager Tiaan, Ayotte Pierre, Hernández-Avila Mauricio, Dewailly Eric
Center for Population Health Research, National Institute of Public Health, Cuernavaca, Morelos, Mexico.
Arch Environ Health. 2004 Jan;59(1):42-9. doi: 10.3200/AEOH.59.1.42-49.
A cross-sectional study was conducted to evaluate nonoccupational biological exposure to 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) compounds and to identify the main factors associated with such exposure in a malaria endemic region in Mexico. Capillary gas column chromatography was used to determine levels of p,p'-DDT and its metabolites in plasma. The mean age of the 144 male participants was 28 yr. Mean p,p'-DDE (1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene) and p,p'-DDT levels were 203.5 microg/l and 67.4 microg/l, respectively. Those whose houses had been sprayed for malaria control had much higher p,p'-DDE levels (p < 0.001). High levels of chlorinated pesticides were found despite being banned in Mexico for agricultural and public health use. Findings demonstrate the role of antimalarial campaigns as a major contributing factor for high DDT plasma levels.
开展了一项横断面研究，以评估1,1,1-三氯-2,2-双（4-氯苯基）乙烷（滴滴涕）化合物的非职业性生物暴露情况，并确定墨西哥疟疾流行地区与这种暴露相关的主要因素。采用毛细管气相柱色谱法测定血浆中p,p'-滴滴涕及其代谢物的水平。144名男性参与者的平均年龄为28岁。p,p'-滴滴伊（1,1-二氯-2,2-双（对氯苯基）乙烯）和p,p'-滴滴涕的平均水平分别为203.5微克/升和67.4微克/升。其房屋曾为控制疟疾而喷洒过药物的人，其p,p'-滴滴伊水平要高得多（p < 0.001）。尽管滴滴涕在墨西哥已被禁止用于农业和公共卫生领域，但仍发现了高含量的氯化农药。研究结果表明，抗疟运动是导致血浆中滴滴涕水平升高的一个主要因素。
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