墨西哥恰帕斯州孕妇的血清滴滴涕和滴滴伊水平。
Serum DDT and DDE levels in pregnant women of Chiapas, Mexico.
作者信息
Koepke Ruth, Warner Marcella, Petreas Myrto, Cabria Angeles, Danis Rogelio, Hernandez-Avila Mauricio, Eskenazi Brenda
机构信息
School of Public Health, University of California at Berkeley, Berkeley, California 94720-7360, USA.
出版信息
Arch Environ Health. 2004 Nov;59(11):559-65. doi: 10.1080/00039890409603434.
Abstract
The authors measured the main ingredients of technical DDT (1,1,1-trichloro-2,2-bis(p-chlorophenyl [p,p'-DDT]) and its principal metabolite, 1,1-dichloro-2,2-bis (p-chlorophenyl)ethylene [p,p'-DDE]) in serum collected from 52 pregnant women in Tapachula, Chiapas, Mexico in 1998. The median lipid-adjusted serum levels for the women were 676 ng/g p,p'-DDT (range: 56-23,169 ng/g) and 4,843 ng/g p,p'-DDE (range: 113-41,964 ng/g). In regression analysis, serum DDT and DDE increased with age (test for trend, p = .022) but decreased with total lactation (test for trend, p < .001). Residence in a house that had ever been sprayed for malaria control was also related to serum DDT and DDE. This study provides evidence of high-level exposure to DDT and DDE among pregnant women living in Chiapas, Mexico, despite countrywide restrictions on its use at the time.
摘要
作者测定了1998年从墨西哥恰帕斯州塔帕丘拉的52名孕妇采集的血清中工业用滴滴涕（1,1,1-三氯-2,2-双（对氯苯基）[对，对'-滴滴涕]）及其主要代谢物1,1-二氯-2,2-双（对氯苯基）乙烯[对，对'-滴滴伊]的主要成分。这些女性经脂质调整后的血清中值水平分别为：对，对'-滴滴涕676纳克/克（范围：56 - 23,169纳克/克），对，对'-滴滴伊4,843纳克/克（范围：113 - 41,964纳克/克）。在回归分析中，血清中滴滴涕和滴滴伊水平随年龄增加（趋势检验，p = 0.022），但随总哺乳期减少（趋势检验，p < 0.001）。居住在曾喷洒过疟疾防治药物的房屋中也与血清中滴滴涕和滴滴伊有关。这项研究提供了证据，表明尽管当时全国范围内对滴滴涕的使用有限制，但居住在墨西哥恰帕斯州的孕妇仍有高水平的滴滴涕和滴滴伊暴露。
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