Venditto Vincent J, Regino Celeste Aida S, Brechbiel Martin W
Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA.
Mol Pharm. 2005 Jul-Aug;2(4):302-11. doi: 10.1021/mp050019e.
Dendrimers are an attractive platform for macromolecular imaging due to the presence of multiple terminal groups on the exterior of the molecule. Through application of appropriate metal ion chelates, large numbers of metal ions for imaging (paramagnetic or radioopaque) and therapy (radioactive particle emitters) may be conjugated to the dendrimer in combination with a targeting vector, through classic organic synthetic techniques. Thus, a large amount of these metal ions potentially may be site specifically delivered directly into the body with the dendrimer as the vehicle with the targeting vector directing the modified dendrimer. The development of targeted macromolecular agents with acceptable blood retention times and selective organ uptake then has the potential for various biological applications. A review of comparative studies of dendrimers with various externally appended imaging and targeting agents is presented herein.
由于分子外部存在多个末端基团，树枝状大分子是大分子成像的一个有吸引力的平台。通过应用合适的金属离子螯合物，大量用于成像（顺磁性或不透射线的）和治疗（放射性粒子发射体）的金属离子可以通过经典有机合成技术与靶向载体结合，连接到树枝状大分子上。因此，大量这些金属离子有可能以树枝状大分子为载体，靶向载体引导修饰后的树枝状大分子，将其位点特异性地直接递送至体内。开发具有可接受的血液保留时间和选择性器官摄取的靶向大分子试剂，进而具有用于各种生物学应用的潜力。本文介绍了树枝状大分子与各种外部附加的成像和靶向试剂的比较研究综述。
