Boddu Sai H S, Bhagav Prakash, Karla Pradeep K, Jacob Shery, Adatiya Mansi D, Dhameliya Tejas M, Ranch Ketan M, Tiwari Amit K
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman P.O. Box 346, United Arab Emirates.
Center of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman P.O. Box 346, United Arab Emirates.
J Funct Biomater. 2021 Oct 8;12(4):58. doi: 10.3390/jfb12040058.
Polymers have always played a critical role in the development of novel drug delivery systems by providing the sustained, controlled and targeted release of both hydrophobic and hydrophilic drugs. Among the different polymers, polyamides or poly(amino acid)s exhibit distinct features such as good biocompatibility, slow degradability and flexible physicochemical modification. The degradation rates of poly(amino acid)s are influenced by the hydrophilicity of the amino acids that make up the polymer. Poly(amino acid)s are extensively used in the formulation of chemotherapeutics to achieve selective delivery for an appropriate duration of time in order to lessen the drug-related side effects and increase the anti-tumor efficacy. This review highlights various poly(amino acid) polymers used in drug delivery along with new developments in their utility. A thorough discussion on anticancer agents incorporated into poly(amino acid) micellar systems that are under clinical evaluation is included.
聚合物在新型药物递送系统的发展中一直发挥着关键作用，它能实现疏水性和亲水性药物的持续、可控和靶向释放。在不同的聚合物中，聚酰胺或聚（氨基酸）具有独特的特性，如良好的生物相容性、缓慢的降解性和灵活的物理化学修饰。聚（氨基酸）的降解速率受构成聚合物的氨基酸亲水性的影响。聚（氨基酸）被广泛用于化疗药物的制剂中，以在适当的时间内实现选择性递送，从而减轻药物相关的副作用并提高抗肿瘤疗效。本综述重点介绍了用于药物递送的各种聚（氨基酸）聚合物及其应用的新进展。还包括对正在进行临床评估的纳入聚（氨基酸）胶束系统的抗癌药物的深入讨论。
