Nagarajan P, Venkatesan R, Kumar M J Mahesh, Majumdar S S
Primate Research center, National Institute of Immunology, New Delhi, India.
J Med Primatol. 2005 Aug;34(4):219-23. doi: 10.1111/j.1600-0684.2005.00108.x.
A mass was identified on the left caudal region of the abdomen in a 13-year-old bonnet monkey (Macaca radiata). The mass was excised and diagnosed as granulosa theca cell tumor accompanied with luteoma based on the microscopic findings. Morphologically it appeared pink, round, firm multilobulated measured approximately 5 x 3 x 2.5 cm in dimension. Histologically the luteoma composed of polyhedral cells with pale strained vacuolated cytoplasm, centrally located nuclei with distinct cytoplasmic borders. Granulosa theca cell tumor appeared as densely packed spindle shaped fusiform cells arranged in interlacing bundles and whorled pattern with neoplastic cells appearing irregular shaped solid sheets. The concomitant development of granulosa theca cell tumor with luteoma in a single ovary is very rare and is the first reported case in a bonnet macaque to our knowledge.
在一只13岁的冠毛猕猴（Macaca radiata）的腹部左尾侧区域发现了一个肿块。该肿块被切除，并根据显微镜检查结果诊断为伴有黄体瘤的颗粒卵泡膜细胞瘤。形态上，它呈粉红色、圆形、质地坚硬，多叶状，尺寸约为5×3×2.5厘米。组织学上，黄体瘤由多面体细胞组成，细胞质苍白、有液泡，细胞核位于中央，细胞质边界清晰。颗粒卵泡膜细胞瘤表现为紧密排列的梭形细胞，呈交错束状和漩涡状排列，肿瘤细胞呈不规则形状的实性片状。单个卵巢中颗粒卵泡膜细胞瘤与黄体瘤同时发生的情况非常罕见，据我们所知，这是首次在冠毛猕猴中报道的病例。
