果蝇Melted蛋白调节FOXO和TOR活性。

Drosophila Melted modulates FOXO and TOR activity.

作者信息

Teleman Aurelio A, Chen Ya-Wen, Cohen Stephen M

出版信息

Dev Cell. 2005 Aug;9(2):271-81. doi: 10.1016/j.devcel.2005.07.004.

DOI:10.1016/j.devcel.2005.07.004

Abstract

The insulin/PI3K signaling pathway controls both tissue growth and metabolism. Here, we identify Melted as a new modulator of this pathway in Drosophila. Melted interacts with both Tsc1 and FOXO and can recruit these proteins to the cell membrane. We provide evidence that in the melted mutant, TOR activity is reduced and FOXO is activated. The melted mutant condition mimics the effects of nutrient deprivation in a normal animal, producing an animal with 40% less fat than normal.

摘要

胰岛素/PI3K信号通路控制着组织生长和新陈代谢。在此，我们确定Melted是果蝇中该信号通路的一种新调节因子。Melted与Tsc1和FOXO相互作用，并能将这些蛋白质招募到细胞膜上。我们提供的证据表明，在melted突变体中，TOR活性降低，FOXO被激活。melted突变体状态模拟了正常动物营养剥夺的影响，产生了一种脂肪比正常动物少40%的动物。