亲吻素与GPR54——哺乳动物促性腺激素释放激素轴的新生物学
Kisspeptins and GPR54--the new biology of the mammalian GnRH axis.
作者信息
Aparicio Samuel A J R
机构信息
University of Cambridge Department of Oncology, Hutchison-MRC Research Centre, Cambridge CB2 2XZ, United Kingdom.
出版信息
Cell Metab. 2005 May;1(5):293-6. doi: 10.1016/j.cmet.2005.04.001.
PMID:16054076
Abstract
Recent genetic evidence in humans and from mouse knockouts has linked kisspeptin-driven GPR54 signaling to the regulation of GnRH release from the hypothalamus. These molecules appear to represent a previously unsuspected control point for GnRH secretion, with important implications for the biology and pathology of the sex steroid axis.
摘要
近期来自人类和小鼠基因敲除实验的遗传学证据表明， kisspeptin驱动的GPR54信号传导与下丘脑促性腺激素释放激素（GnRH）的释放调节有关。这些分子似乎代表了一个此前未被怀疑的GnRH分泌控制点，对性类固醇轴的生物学和病理学具有重要意义。
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