Colledge William H
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK.
Trends Endocrinol Metab. 2009 Apr;20(3):115-21. doi: 10.1016/j.tem.2008.10.005. Epub 2008 Dec 25.
Kisspeptin binding to its G-protein-coupled receptor KISS1R (also known as GPR54), which is expressed by gonadotropin-releasing hormone (GnRH) neurons, stimulates GnRH release and activation of the mammalian reproductive axis. Kisspeptin neurons make close contact with GnRH neurons acting at both the cell body and the nerve terminals. Kisspeptin can act directly on GnRH neurons and/or indirectly via synaptic input from other neurons to inhibit inwardly rectifying potassium channels and activate non-specific cation channels, with the effect of long-lasting depolarization and increased action potential firing rate. This review covers the recent advances in the molecular consequences of kisspeptin action on GnRH neurons and how these neuronal circuits are integrated in different species. These studies provide insight into the mechanism by which kisspeptin regulates the reproductive axis.
亲吻素与其G蛋白偶联受体KISS1R（也称为GPR54）结合，该受体由促性腺激素释放激素（GnRH）神经元表达，刺激GnRH释放并激活哺乳动物生殖轴。亲吻素神经元与作用于细胞体和神经末梢的GnRH神经元紧密接触。亲吻素可直接作用于GnRH神经元和/或通过其他神经元的突触输入间接作用，以抑制内向整流钾通道并激活非特异性阳离子通道，产生持久去极化和增加动作电位发放频率的效果。本综述涵盖了亲吻素作用于GnRH神经元的分子效应的最新进展，以及这些神经回路在不同物种中是如何整合的。这些研究为亲吻素调节生殖轴的机制提供了见解。
