南非传统镇静及可能具有中枢神经系统作用的植物在γ-氨基丁酸-苯二氮䓬受体检测中的活性
Activity of traditional South African sedative and potentially CNS-acting plants in the GABA-benzodiazepine receptor assay.
作者信息
Stafford Gary I, Jäger Anna K, van Staden Johannes
机构信息
Research Center for Plant Growth and Development, School of Biological and Conservation Sciences, University of KwaZulu-Natal Pietermaritzburg, Scottsville 3209, Pietermaritzburg, South Africa.
出版信息
J Ethnopharmacol. 2005 Aug 22;100(1-2):210-5. doi: 10.1016/j.jep.2005.04.004.
Several plants are traditionally used to treat mental diseases in South Africa. Forty-six ethanol extracts from 35 species, both indigenous and exotic that are traditionally used predominantly as sedatives or to treat various CNS-related ailments were tested in the GABAA-benzodiazepine receptor-binding assay. In this assay, the binding of 3H-Ro 15-1788 (flumazenil) to the benzodiazepine site is measured. The GABAA-benzodiazepine receptor complex is involved in sedation, epilepsy and convulsions. Out of the 46 extracts tested, seven showed good activity and 10 showed moderate activity. The most active extracts were the ethanolic leaf extracts of Arctopus echinatus, Artemisa afra, four Helichrysum species and Mentha aquatica which all showed good dose-dependent activity.
在南非，有几种植物传统上被用于治疗精神疾病。对来自35个物种的46种乙醇提取物进行了测试，这些物种包括本土的和外来的，传统上主要用作镇静剂或治疗各种与中枢神经系统相关的疾病，测试采用γ-氨基丁酸A型（GABAA）-苯二氮䓬受体结合试验。在该试验中，测量3H-罗15-1788（氟马西尼）与苯二氮䓬位点的结合情况。GABAA-苯二氮䓬受体复合物与镇静、癫痫和惊厥有关。在测试的46种提取物中，7种显示出良好活性，10种显示出中等活性。活性最强的提取物是刺苞果、南非艾菊、4种蜡菊属植物和水生薄荷的乙醇叶提取物，它们均显示出良好的剂量依赖性活性。
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