Hughes W T, Smith B L
Antimicrob Agents Chemother. 1983 Aug;24(2):300-1. doi: 10.1128/AAC.24.2.300.
An intermittent regimen of trimethoprim-sulfamethoxazole was tested in the corticosteroid-treated rat model to learn whether or not administration for 3 consecutive days a week would provide prophylaxis equal to continuous daily doses. Although all of the untreated control animals acquired Pneumocystis carinii pneumonia, none of the animals given either continuous or intermittent trimethoprim-sulfamethoxazole became infected.
在接受皮质类固醇治疗的大鼠模型中测试了甲氧苄啶-磺胺甲恶唑的间歇给药方案，以了解每周连续给药3天是否能提供与每日连续给药相同的预防效果。尽管所有未治疗的对照动物都感染了卡氏肺孢子虫肺炎，但接受连续或间歇给药的甲氧苄啶-磺胺甲恶唑的动物均未感染。
